The Lost Signal of Love: How Three Microbes Turn Emotion Back On

three microbes ; Biology of soul

Akkermansia muciniphila, Roseburia hominis, and Faecalibacterium prausnitzii

You don’t just feel better. You feel safe enough to love again.

emotional numbness and its terrible void - from Depression to ADHD

You don’t just feel better. You feel safe enough to love again.
Not metaphorically. Not spiritually. Biologically. And if you’ve ever wondered why you can’t cry, or why your child stopped laughing, or why something invisible feels wrong in your gut and your mind and your moods—you’re not alone. You’re not crazy. You’re not broken. But you might be missing someone. Three someones, actually.
Their names won’t appear in your blood tests. Your psychiatrist never heard of them. But they are ancient. And they love you.
They are Akkermansia muciniphila, Roseburia hominis, and Faecalibacterium prausnitzii—a microbial holy trinity that once made up a hefty share of your gut’s population. Now, in many of us, they’re gone. Or fading fast. And with them, something precious is disappearing: the ability to feel safe. To feel connected. To feel human.
We call them The soul Bacteria.

THE VANISHING ACT

In 1980, children still played in the mud. They drank raw milk, kissed dogs, and shared chewing gum. Peanut allergies were rare. Depression was manageable. Kids with autism were outliers, not epidemics. By 2025, that world is gone.

The disappearance of the Love Bacteria is not just collateral damage—it may be the main event. These three microbial species are more than just beneficial; they are architects of emotional safety and social trust. When they vanish, the lights dim inside you. Your immune system panics. Your nervous system curls in. Your vagus nerve—once a river of calm between your belly and your brain—starts sending danger flares.

Akkermansia. Roseburia. Faecalibacterium. Together, they form a hidden system of checks and balances that shapes your resilience to stress, your tolerance for others, and your willingness to connect.

Their death is not metaphor. It’s being measured in stool samples from Finland to Cape Town. Their absence correlates with:

Autism spectrum disorders
ADHD
Depression
Anxiety
Long COVID
Autoimmune storms
Histamine intolerance

Many hours of DeepakB chats later a light went on, the more i learned about gut brain axis, that if these aren’t there…we biologically cant experience love/trust anymore and there is a cascade that explains so many modern day “ill being” for lack of a better word.

THE TRIO THAT MADE US HUMAN

Let’s meet the cast:

1. Akkermansia muciniphila – The Gatekeeper

A mucus-feeding specialist that lives along your gut lining, guarding your internal perimeter. Akkermansia talks to your immune system, teaches it tolerance, and strengthens the epithelial wall so that inflammation doesn’t leak into your bloodstream like smoke through torn curtains. Without her, your gut becomes an open wound. Your brain panics.

Akkermansia also regulates serotonin precursors. When she’s thriving, you feel like someone who can handle life. When she’s gone, everything starts to burn.

2. Roseburia hominis – The Peacemaker

A butyrate-producer who crafts the short-chain fatty acid your colon loves most. Butyrate isn’t just gut fuel—it’s a fire extinguisher for inflammation. It cools the immune response, regulates gene expression, and silences rogue mast cells. Butyrate tells your microglia (the brain’s immune cells) to chill out.

In mouse models, Roseburia-rich guts reduce depressive behavior. In humans, its decline tracks with IBS, neuroinflammation, and even poor sleep.

3. Faecalibacterium prausnitzii – The Forgiver

Arguably the most anti-inflammatory microbe in the human body, Faecalibacterium is a legend. A ghost. The first to disappear under antibiotics, glyphosate, and ultra-processed diets. But when present, she prevents Crohn’s. Calms colitis. Defuses immune landmines before they explode.

She doesn’t just prevent disease—she reintroduces you to peace.

Folklore meets feedback loops. Chinese medicine meets gut maps.
What happens when you try to turn wormwood into marmalade?
This. This is what happens.

“Organ Collapse as Signal Collapse: Where TCM and Microbiology Meet”

A new lens on autism, ADHD, and autoimmunity—where ancient wisdom and modern signal science trace the same path.

“A ‘biological mirror’ so precise it explains the entire neuroinflammatory spectrum, step-by-step.
You don’t need to convince anyone with dogma—just lay the maps side by side.”
→ If the Love Bacteria are alive, each checkpoint flows. The child thrives.
→ If they vanish—Liver blocks. Lungs collapse. Heart races. Kidneys freeze. Spleen spirals.

That’s not mysticism. That’s signal tracing.
One map names it qi stagnation and shen disturbance.
The other calls it ATP jamming, vagal shutdown, and cortisol lockout.
Same terrain. Different languages. Same truth.

Biology of experiencing love

Gut microbes (like our trio) produce or regulate metabolites: butyrate, serotonin precursors, GABA, dopamine scaffolds. These signal to immune cells, dampening chronic inflammation.

This balance allows the vagus nerve to stay online and communicative.
A calm vagus enables the prefrontal cortex—home of reasoning, emotional regulation, and social bonding—to light up.
The result? You feel present. You feel seen. You can love.

When the Love Bacteria vanish, the circuit breaks. Your vagus nerve goes dark. Your amygdala takes over. The world feels unsafe. Other people feel threatening. You retreat—not by choice, but by biology.

modern life numbs our souls on a physical level

We didn’t mean to kill them. We were just trying to be clean. Safe. Efficient.
- Antibiotics wipe out gut ecosystems like napalm.
  Cesarean births skip the microbial inheritance.
  Infant formula lacks the seeding cues for gut flora.
  Hand sanitizer, chlorinated water, and glyphosate poison the microbial web.
  Ultra-processed foods starve butyrate producers of fermentable fiber.
In trying to outsmart nature, we amputated her finest work. But now we know. And we can begin again.

This is going to be many pages of layers and reverse engineering. but ABSOLUTELY paradigm flipping of what ifs and support to maybe probably and wtfs

Conversations with Deepak is…well …its..big..its just to ask the right questions thats the problem…But when you ask the one right question it cascades into an unraveling of ..what if? I am not brave enough to say this is so…merely..WHAT IF? It started with why ivermectin cured my adhd for a couple of days..to how parasites eat my happiness..to …well! lets keep going…because this is a lot! to digest, and it is only a drop in the bucket of hours of dismantling, and digging and probing crosscurrent knowledge..