And Choline Fails Because the Terrain Is Gone

Let’s burn this into the wall.

You feel better on nicotine because it mimics acetylcholine — your body’s “YES” signal.
The signal of:

• Movement

• Focus

• Digestion

• Calm

• Repair

But acetylcholine isn’t conjured out of willpower.
It’s built. Brick by brick. Cell by cell. Bug by bug.

And what does that take?

• Functional enzymes

• Methylation pathways

• Vagal responsiveness

• And microbial support

This is where the Love Trio enters — not as hippie probiotics,
but as the biochemical midwives of your nervous system.

🧬 The Love Trio’s Role in Choline and Acetylcholine

Let’s call names. Let’s get anatomical.

Akkermansia muciniphila

• Feeds on gut mucus

• Thickens and protects the lining where choline is absorbed

• Keeps your immune system from static interference

• Supports lipid metabolism — key for acetylcholine packaging

Faecalibacterium prausnitzii

• Pumps out butyrate → calms fire, heals tissue

• Activates choline acetyltransferase (converts choline to acetylcholine)

• Maintains the intestinal barrier — so choline gets in and used

Roseburia spp.

• Also makes butyrate

• Stimulates motility and vagus activation

• Helps manage bile acids — critical for fat-soluble choline absorption

Together, these three:

• Ensure choline enters

• Ensure it gets transformed

• Ensure the signal gets sent

Lose them?
You can eat a carton of egg yolks and still go signal-silent.

🔥 Nicotine Relief = Microbial Failure

Let’s get uncomfortable:

Why does nicotine help with ADHD, colitis, Alzheimer’s, long COVID?

Because it bypasses terrain.
It doesn’t fix.
It fakes.

It’s the molecular ghost of a function your body used to perform.

Like hearing a violin solo not from your fingertips,
but from a speaker taped to your chest.

It sounds right.
It feels like you.
But it’s not coming from you.

🧪 Proof in the Patterns

Let’s tear the curtain down.

If nicotine cured these conditions, smokers would be immune to dementia.
They’re not.

What we do see:

• It sharpens, then crashes

• It soothes, then spins out

• It quiets the gut, then chaos returns

Why?

Because:

• It mimics, not restores

• It skips the gut-brain circuitry

• It shouts at the receptor without fixing the amplifier

🌱 Rebuild the Symphony

We don’t want nicotine’s karaoke version of healing.
We want our own voice back.

That means rebuilding the terrain:

• Akkermansia → pomegranate peel, fermented kvass, polyphenols

• Faecalibacterium → goat whey, diverse fibers, contact with living soil

• Roseburia → resistant starches, herbal bitters, fat digestion support

And from there:

• Choline flows

• Acetylcholine wakes

• The vagus listens

• The fog lifts