THE NEUROINFLAMMATORY SPECTRUM: A MAP FOR REBOOTING ADHD, AUTISM, AND BEYOND

biology or soul expression in the physical

🧠 Emotion shapes biology—yes.
But also:
🧬 Biology enables emotion—equally true.

And that’s the axis we’re about to walk:
the razor’s edge where psychology meets microbiology,
where psychiatry must finally confess its blind spot,
and where neurology surrenders to terrain.

I. The Great Unknotting

There is no single autism.
No single ADHD.

Just like there is no single war—only patterns of terrain disruption that call for different survival responses.

Autism is freeze. ADHD is flee.
Two wings of the same bird. A bird caught in a biochemical storm it never chose.

This isn’t a story about broken brains. This is a story about hijacked signals.
About a forgotten class of molecules—the purines—that scream danger long after the fire’s out.
It’s about parasites that whisper fear into your bones. Microbes that dictate your serotonin. Inflammation that stuns the vagus and traps the gaze.

And it’s about something more ancient still:
The collapse of the internal village.
A collapse that happens not just in the gut, but in the gut’s memory of safety.

II. Purinergic Storm: How the Body Mistakes Signal for Siege

Let’s start here:

When cells are damaged, they release ATP—not for energy, but as a distress signal.

This is the territory of purinergic signaling. A bioelectrical alarm system that tells the body, “Something is wrong.”

Suramin—an old drug used for African sleeping sickness—briefly made headlines when it temporarily reversed autism symptoms in children. The reason? It silenced this purinergic alarm.

The children made eye contact again. Spoke. Laughed.
Then the effect wore off.

That glimpse? That was the nervous system finally hearing silence after years of molecular screaming.

But what if that silence didn’t have to come from a century-old pharmaceutical?
What if we could reboot the terrain itself?

III. The Collapse of the Love Bacteria

The body is a parliament. Most members we never meet.

But three of them—Akkermansia, Faecalibacterium, and Roseburia—are the sacred triad we now call the Love Bacteria.

They produce butyrate, nourish the colon lining, regulate inflammation, and keep the immune system from panicking.

And when they disappear?

The gut becomes permeable.
Mast cells explode.
The vagus nerve falters.
Estrogens can’t be processed.
Histamines go wild.

And suddenly, everything hurts. Sound. Light. Touch. Food. Social gaze.

IV. Two Responses to the Same Fire

Picture a child with an inflamed terrain.

The microglia (brain immune cells) are on high alert. ATP is flooding the system as a distress call. The vagus nerve is suppressed. Safety cues can’t get through.

Now the body makes a choice:

Freeze, shut down, withdraw (Autism response)
Flee, dart, interrupt, move (ADHD response)

One isn’t more broken than the other. They’re both adaptations to the same war.

This is the Neuroinflammatory Spectrum.
Not a psychiatric diagnosis, but a map.

A map that shows us how to treat the terrain, not the label.

V. Mapping the War: What Gets Lost

When the Love Bacteria collapse, a domino effect begins:

Lost Function	Biological Fallout	Emotional Echo
Butyrate production	Colon inflammation, leaky gut	Heightened sensory pain
Estrogen metabolism	Hormone imbalance, fatty liver	Mood swings, aggression
GABA signaling	Vagus suppression, poor sleep	Anxiety, emotional fragility
Tryptophan conversion	Low serotonin, high quinolinic acid	Depression, social retreat
Endocannabinoid balance	Dysregulated stress response	Panic, food aversions
ATP off-switch	Chronic purinergic inflammation	Brain fog, loss of focus

These aren’t psychological choices.
They’re terrain responses.

And when we repair the terrain, the personality often changes—because the biology allows it.

VI. The Reset: Triage, Terrain, Trust

This isn’t about silver bullets.
This is about sequencing.

Stop the threat — Calm the purinergic storm, reduce ATP distress signals. This may come from herbal suramin-mimics, parasite clearing, or mast cell stabilizers.
Rebuild the village — Restore butyrate producers, estrobolome support microbes, and vagus toning via breath, light, fermented foods, and kinship.
Rewire the safety map — Only then can the brain begin to re-map safety. Only then does talk therapy, eye contact, co-regulation, and social learning become biologically possible.

Because:

🧠 You don’t just feel better.
🫀 You feel safe enough to feel.

“If the Love Bacteria are alive → Each checkpoint flows → Child thrives.
If they vanish → Liver blocks, Lungs collapse, Heart races, Kidneys freeze, Spleen spirals.”